The blood brain barrier, which comprises a tight seal of cells that line the blood vessels in the brain, makes it difficult for many substances to cross from the bloodstream into the central nervous system (CNS). The barrier’s complex structure and function provides many challenges that have to be overcome when developing drugs that specifically target the CNS. The TRANSIL Brain Absorption Assay is performed in our labs to assess your drug candidate’s ability to cross the blood brain barrier. The assay directly assesses a drug candidate or other test substances affinity for the brain’s membrane, which is directly related to permeation and blood-to-brain absorption. In conjunction with our protein binding assay is is also possible to predict a test substances equilibrium distribution between plasma and brain tissue.
To find out further information or to receive advice about your specific needs, please contact our dedicated contract research team: service@sovicell.com.
The Sovicell service advantage:
To find out further information or to receive advice about your specific needs, please contact our dedicated contract research team: service@sovicell.com.
