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2/28/2008Nimbus changes name to Sovicell and launches new website2/20/2008Sovicell announces winner of the iPod raffle1/25/2008Presentation of first validation data for the TRANSIL blood-to-brain absorption kit at the predictive human toxicity/ADME-Tox meeting in Brussels9/1/2007Release of TRANSIL Blood-to-Brain absorption kit

Science & Technology

Publications

• The binding of advanced glycation end products to cell surfaces can be measured using bead-reconstituted cellular membrane proteins.
  Schmitt, A., Nöller, J., Schmitt, J.
  Biochim.Biophys.Acta-Biomembranes (2007), in press

• ADME related profiling in 96 and 384 well plate format- A novel and robust HT-assay for the determination of lipophilicity and serum albumin binding.
  Hartmann, T., Schmitt, J., Röhring, C., Nimptsch, D., Nöller, J., Mohr, C.
  Current Drug Delivery 3 (2006) 181-192

• From Early Drug Discovery to Clinical Trials
  Nöller, J., Schmitt, J., Hartmann, T., Löffler, T
  Screening: Trends in Drug Discovery Vol. 6 (3, 2005) 48-49

• Just Married – in vitro and in silico ADME Prediction
  Nöller, J., Schmitt, J., Hartmann, T.
  Screening: Trends in Drug Discovery Vol. 6 (1, 2005) 32-33

• Role of lipophilicity and protein binding in ADME prediction
  Nöller, J., Schmitt, J. Machamer, J.
  Drug Plus International (Nov. 2005) 1-3

• Characterization of advanced glycation end products for biochemical studies: Side chain modifications and fluorescence characteristics.
  Schmitt, A, Schmitt, J, Münch, G, Gasic-Milenkovic, J
  Anal. Biochem. 338 (2005) 201-215

• Characterization of advanced glycation end products: Mass changes in correlation to side chain modifications.
  Schmitt, A, Gasic-Milenkovic, J, Schmitt, J
  Anal. Biochem., 346 (2005) 101–106

• Two analytical methods to study the interaction of AGEs with cell surface proteins.
  Schmitt A., Meiners I., Schmitt J., Nöller J., Ihling Ch., Sinz, A., Münch G., Nieber, K.
  J. Biochem. Biophys. Meth. 65 (2005) 121-36

• Lipophilicity- beyond octanol/water: a comparison of modern technologies
  Hartmann T. and Schmitt J.
  Drug Discovery Today: Technologies 1 (4, 2004) 431-439

• Multilamellar liposomes and solid-supported lipid membranes (TRANSIL): Screening of lipid-water partitioning towards a high-throughput scale
  Loidl-Stahlofen A., Hartmann T., Schöttner M., Röhring C., Brodowsky, H., Schmitt, J., Keldenich, J.
  Pharm. Res. 18 (12, 2001) 1782-1788

• Polymer Cushions in Supported Phospholipid Bilayers Reduce Significantly the Frictional Drag between Bilayer and Solid Surface
  Schmitt J., Danner B., Bayerl T.M.
  Langmuir, 17 (2001) 244-246

• Solid-Supported Biomolecules on Modified Silica Surfaces – A tool for fast physicochemical characterization and High-Throughput Screening
  Loidl-Stahlofen A., Schmitt, J., Nöller J., Hartmann T., Brodowsky, H., Schmitt W., Keldenich, J.
  Adv. Materials, 13 (23, 2001) 1829-1834

• Solid-Supported Lipid Membranes as a Tool for Determination of Membrane Affinity: High-Througput Screening of a Physicochemical Parameter
  Loidl-Stahlofen A., Eckert A., Hartmann T., Schöttner M.
  J. Pharm. Sci. 90 (2001) 599-606
  

• Physiology-based pharmacokinetic modelling: ready to be used
  Schmitt W. and Willmann S.
  Drug Discovery Today: Technologies 1 (4, 2004) 449-456

• A Physiological Model for the Estimation of the Fraction Dose Absorbed in Humans
  Willmann, S.; Schmitt, W.; Keldenich, J.; Lippert, J.; Dressman, J.B.
  J. Med. Chem. 47 (16, 2004) 4022-4032

• High-Throughput Determination of the Free Fraction of Drugs strongly Bound to Plasma Proteins
  Schuhmacher J., Kohlsdorfer C., Bühner K., Brandenburger T., Kruk R. J.
  Pharm. Sci. 93 (2004) 816-830